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šŸ¦˜Cacatman's Personal Coronavirus COVID-19 Update Thread

cacatman

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School Information - Asymptomatic Infections in Children
Small sample size, but about 20% of infected children are asymptomatic.

and percentage of asymptomatic children in a population is the same as the numbers of new cases....

COVID-19 Risk Factors in Children
More likely to have been in close contact with someone with a confirmed case of the virus and are less likely to have had
consistent mask use.
School attendance was NOT found to increase likelihood of testing positive.

The study (looking at spread in households) found that susceptibility to COVID-19 among children younger than 20 was 43% (95% CI: [31%, 55%]) of the susceptibility of adults and infectivity of children was 63% (95% CI: [37%, 88%]) of infectivity of adults.

The study found that the odds of testing positive for COVID-19 increased with age until about age 20 and remained constant thereafter.

About 36% of children who tested positive for COVID-19 were asymptomatic.
 

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cacatman

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Treatment - Tocilizumab & Sarilumab may improve survival
Interleukin-6 receptor antagonists may improve outcomes of critically ill. Better results with these drugs in patients in ICU & had started organ support.

N.B. 3 previous studies had mixed results.
 

cacatman

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Shorter Quarantines Can Eliminate Most Contagion
In household contacts who were asymptomatic on day 5 with a negative test on day 5, 71 percent remained both negative and symptom-free for 14 days. By day 7, 91 percent of negative patients remained negative and asymptomatic by day 14 and by day 10 the number climbed to 93 percent.
 

cacatman

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Risk Factors - Hypertensive patients are more likely to be seriously ill
Because immune cells are already "pre-activated", but ACE Inhibitors can have a beneficial effect. They lower BP, but also counteract immune hyper activation.

There is also no increased risk in those taking antihypertensive drugs.
 

cacatman

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Treatment - Convalescent Plasma Not Helpful
No significant differences were observed in clinical status or overall mortality between patients treated with convalescent plasma and those who received placebo.

REMAP-CAP is an international clinical trial exploring potential treatments for COVID-19. It has already recruited 4,100 COVID-19 patients at more than 290 clinical sites across Europe, the Americas, Asia, Africa and Australasia.

Found no benefit.
 

cacatman

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Apple Watches Can Possibly Signal Early Infection!!
When it comes to COVID-19, individuals infected with the disease experience lower heart rate variability compared to those who tested negative. The study followed 300 health workers at Mount Sinai who wore Apple Watches for five months.

81% of those who tested positive for coronavirus experienced changes in their resting heart rates.

 

cacatman

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J & J Vaccine - 90% Efficacious
After a single dose vaccination, data showed neutralizing antibodies against COVID-19 were detected in over 90 percent of study participants at Day 29 and 100% of participants aged 18-55 years at Day 57. These neutralizing antibodies remained stable through Day 71, currently the latest timepoint available in this ongoing study, in all participants aged 18-55 years.
 

cacatman

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New Strain
SARS-CoV-2, B.1.1.7, or otherwise known as VOC 202012/01, which was discovered in the United Kingdom back in December may lead to a large increase in the number of COVID-19 cases.
Investigators have said B.1.1.7 is more contagious than the original virus, but no determination has been made that this variant can lead to severe cases and higher mortality.
 

cacatman

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Long Haulers/Long Covid

Definition
- ā€œsigns and symptoms that develop during or following an infection consistent with COVID-19 which continue for more than 12 weeks and are
not explained by an alternative diagnosis.ā€

Almost a third of recovered COVID-19 patients in a UK study ended up back in the hospital within five months ā€” and up to one in eight died of complications from the illness.

Researchers at the UKā€™s Leicester University and the Office for National Statistics found that out of 47,780 people discharged from the hospital, 29.4 percent were readmitted within 140 days.

Of the total, 12.3 percent ended up dying.

Respiratory disease was diagnosed in 14,140 of the COVID cases after discharge, with 6,085 of the diagnoses in patients who had no history of respiratory conditions.

The mean age of study participants was 65 years.

Weeks and months later, some people who have had COVID-19 continue to have problems. Came out of Italy. published in JAMA. 179 sample size. 143 overall. Mean age 56 yo. 63% men. 73% had pneumonia. Average length of stay 2 weeks. BMI average 26. Most had symptoms 2 months later.13% had no symptoms at 2 months. 32% had 1-2 symptoms. 55% had 3+ symptoms as at the beginning. 44% said their quality of life got worse!!! Fatigue, dyspnoea, joint pain and chest pain, cough could all still remain. Seems to be worse in the morning. Telogen Effluvium (temporary hair loss) also seems to occur.


Info about the so called "Long haulers"

Overall, the chance of being impacted by long covid increased with age. Long COVID was found to affect around 10% of 18-49 year olds who become unwell with coronavirus, rising to 22% of over 70s.
The team found that while most people with COVID-19 reported being back to normal in 11 days or less, around one in seven (13.3%) had COVID-19 symptoms lasting for at least four weeks, with around 1 in 20 (4.5%) staying ill for eight weeks and 1 in 50 (2.3%) suffering for longer than 12 weeks.

Mental Health is an issue also. See here.

In this cohort of individuals with COVID-19 who were followed up for as long as 9 months after illness, approximately 30% reported persistent symptoms. A unique aspect of our cohort is the high proportion of outpatients with mild disease. Persistent symptoms were reported by one-third of outpatients in our study, consistent with a previously reported study,4 in which 36% of outpatients had not returned to baseline health by 14 to 21 days following infection. However, this has not been previously described 9 months after infection.

Consistent with existing literature, fatigue was the most commonly reported symptom.2-4This occurred in 14% of individuals in this study, lower than the 53% to 71%2-4 reported in cohorts of hospitalized patients, likely reflecting the lower acuity of illness in our cohort. Furthermore, impairment in HRQoL has previously been reported among hospitalized patients who have recovered from COVID-19; we found 29% of outpatients reported worsened HRQoL.
 

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