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šŸ¦˜Cacatman's Personal Coronavirus COVID-19 Update Thread

cacatman

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Vaccination Reduces Infection Rates & (Most Likely) Transmission
  1. Vaccinated people tend to have lower viral loads.
  2. Lower viral loads are linked to less viral spread.
  3. Data showed 94% fewer symptomatic coronavirus cases and 92% fewer cases of serious illness among those vaccinated

 

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cacatman

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Israel's Vaccination Experience
Israel has given the first shot to 4.2 million peopleā€”more than two-thirds of eligible citizens over 16 years oldā€”and a second shot to 2.8 million, according to its health ministry. The country has around 9.3 million citizens.
The study, which involved about 9,000 people, also found a 75% reduction in both symptomatic and asymptomatic infections after the first shot. The study was published as a correspondence, meaning it represents the views of the authors and not the Lancet.
 

cacatman

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Complications - Post Hospital Heart Damage Lingers
Heart damage is present in a significant number of COVID-19 patients after they have been hospitalized with elevated troponin levels, according to new findings published in the European Heart Journal.

The studyā€™s authors used MRI examinations to evaluate 148 COVID-19 patients. All patients had elevated troponin levels and were treated at one of six hospitals in London during the pandemicā€™s first few months. The images were obtained at least one full month following discharge, suggesting the identified damage can remain for a considerable amount of time. Forty healthy volunteers also underwent MRI scans to provide the analysis with a control group.

Overall, signs of heart damageā€”which included inflammation, scarring and restricted blood supply to the heartā€”were present in 54% of patients. The heartā€™s left ventricle did appear to be free of damage and functioning properly for 89% of patients.
 

cacatman

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Anaphylaxis 11.1/million with Pfizer Vaccinations
In general, anaphylaxis occurs in 1.3 per 1 million vaccinations, but it appears to occur somewhat more frequently after COVID-19 vaccination, notes David M. Lang, MD, Chair of the Department of Allergy and Clinical Immunology in Cleveland Clinicā€™s Respiratory Institute.

According to the CDC, 21 cases of anaphylaxis have been reported following the nearly 1.9 million Pfizer-BioNTech vaccinations administered in the U.S. as of Dec. 23, 2020. Thatā€™s a rate of 11.1 per 1 million vaccinations.

Most people didnā€™t have side effects. A little over 50% didnā€™t experience any side effects at all and remember, they were still 94% protected after receiving the vaccine. So, you donā€™t need to worry if you donā€™t have any symptoms after your COVID-19 vaccinations.
 

Lopaka KaMars

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And now back to your regularly scheduled programs. šŸ˜

Apologies @cacatman. Couldn't help myself.
 

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cacatman

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cacatman

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Anosmia
The study also found that patients generally developed anosmia 4.4 days after the onset of the SARS-CoV-2 infection, with a duration of 8.96 days, and 98% of patients could recover within 28 days
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265845/#bb0135

The study also found that patients generally developed anosmia 4.4 days after the onset of the SARS-CoV-2 infection, with a duration of 8.96 days, and 98% of patients could recover within 28 days

16% will only report loss of smell as only symptom of COVID. Anosmia and loss of smell in the era of covid-19

Loss of smell was also significantly associated with decreased hospitalization (OR, 0.69; 95% CI, 0.47-0.99), intensive care unit admission (OR, 0.38; 95% CI, 0.30-0.70), intubation (OR, 0.43; 0.21-0.89), and acute respiratory distress syndrome (OR, 0.45; 95% CI, 0.23-0.89) when compared with patients without loss of smell.

Loss of Taste (Ageusia) and Smell (Anosmia)
47-80% lose this, especially in asymptomatic or mild disease because tongue has ACE2 receptors


People with COVID-19 may lose their sense of smell and taste for up to five months after infection
 

cacatman

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Treatment - Ivermectin
May be helpful in reducing mortality in those with severe pulmonary symptoms

15/12/20
Prospective randomised blinded trials - Gold standard for investigating.
Ivermectin has only had retrospective/anecdotal trials. Some evidence it may help BUT NOT STRONG. MORE TRIALS need to be done.

Merck Statement on Ivermectin use During the COVID-19 Pandemic​

  • No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
  • No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
  • A concerning lack of safety data in the majority of studies.

Findings In this randomized clinical trial that included 476 patients, the duration of symptoms was not significantly different for patients who received a 5-day course of ivermectin compared with placebo (median time to resolution of symptoms, 10 vs 12 days; hazard ratio for resolution of symptoms, 1.07).

Meaning The findings do not support the use of ivermectin for treatment of mild COVID-19, although larger trials may be needed to understand effects on other clinically relevant outcomes.
 

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