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🦘Cacatman's Personal Coronavirus COVID-19 Update Thread

cacatman said:
Most COVID-19 is Spread by 18-24 yo (USA)

57 percent of those new cases occurred in people 18 to 24 yo.

“It has been reported that mitigation behaviors, such as social distancing, wearing masks, and avoiding crowded spaces, is lowest among people between the ages of 18 and 29,” he told Healthline.

“They’re more likely to be asymptomatic and can easily unknowingly transmit the virus to others,” Russell said. “Many young adults also know that their risk of lethal infection or developing long-term health problems as a result of the virus is very low, which decreases their anxiety about getting sick and lends them less reason to adhere to COVID-19 recommended practices.”
www.cdc.gov

COVID-19 Trends Among Persons Aged 0–24 ...

Coronavirus disease 2019 (COVID-19) case and electronic laboratory data reported to CDC were analyzed to describe demographic characteristics, underlying health conditions ...
www.cdc.gov www.cdc.gov

Recent hospitalizations among children for COVID-19 were nearly 9 times higher than last spring.
jamanetwork.com

Trends in Pediatric Hospitalizations for Coronavirus Disease 2019

This study examines coronavirus disease 2019 hospitalization trends for pediatric patients in 22 states.
jamanetwork.com jamanetwork.com
Click to expand...
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Mental Illness & COVID-19
The incidence of any psychiatric diagnosis in the 14 to 90 days after COVID-19 diagnosis was 18·1% (95% CI 17·6–18·6), including 5·8% (5·2–6·4) that were a first diagnosis.

Overall, the estimated incidence of being diagnosed with a neurological or mental health disorder following COVID-19 infection was 34%. For 13% of these people it was their first recorded neurological or psychiatric diagnosis.

The most common diagnoses after COVID-19 were anxiety disorders (occurring in 17% of patients), mood disorders (14%), substance misuse disorders (7%), and insomnia (5%). The incidence of neurological outcomes was lower, including 0.6% for brain haemorrhage, 2.1% for ischaemic stroke, and 0.7% for dementia

This latest study analysed data from the electronic health records of 236,379 COVID-19 patients from the US-based TriNetX network, which includes more than 81 million people.
www.thelancet.com

6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records

Our study provides evidence for substantial neurological and psychiatric morbidity in the 6 months after COVID-19 infection. Risks were greatest in, but not limited to, patients who had severe COVID-19. This information could help in service planning and identification of research priorities...
www.thelancet.com
eurekalert.org

The Lancet Psychiatry: Largest study to date suggests link between COVID-19 infection and subsequent mental health and neurological conditions

One in three COVID-19 survivors received a neurological or psychiatric diagnosis within six months of infection with the SARS-CoV-2 virus, an observational study of more than 230,000 patient health records published in The Lancet Psychiatry journal estimates. The study looked at 14 neurological...
eurekalert.org

Prevalence of depression symptoms in the US was more than 3-fold higher during COVID-19 compared with before the COVID-19 pandemic. Individuals with lower social resources, lower economic resources, and greater exposure to stressors (eg, job loss) reported a greater burden of depression symptoms.
jamanetwork.com

Prevalence of Depression Symptoms in US Adults Before and During the COVID-19 Pandemic

This survey study examines the prevalence of depression symptoms among US adults during the coronavirus disease 2019 (COVID-19) pandemic compared with before the pandemic.
jamanetwork.com jamanetwork.com
 

Last edited:
CO2 Levels in Rooms is a proxy for viral load
Wherever you are sharing air, the lower the CO2, the lower risk of infection.

Tracking carbon dioxide levels indoors is an inexpensive and powerful way to monitor the risk of people getting COVID-19, according to new research from the Cooperative Institute for Research in Environmental Sciences (CIRES) and the University of Colorado Boulder.
medicalxpress.com

Carbon dioxide levels reflect COVID-19 risk

Tracking carbon dioxide levels indoors is an inexpensive and powerful way to monitor the risk of people getting COVID-19, according to new research from the Cooperative Institute for Research in Environmental Sciences (CIRES) and the University of Colorado Boulder. In any given indoor...
medicalxpress.com medicalxpress.com
 

Excess Mortality and Potential Life Years Lost
During the pandemic, the U.S. lost an additional 3.6 million potential years of life in 2020. Among excess deaths in 2020, the average person lost 14 years in the U.S. compared to an average of 8 years in peer countries before the age of 75. Excess mortality rates were higher among younger people of color, in part, leading to higher premature excess deaths among people of color in the U.S. Of the potential years of life lost in the U.S., 30% were among Black people and another 31% were among Hispanic people, compared to their share of the U.S. population at 12.2% and 18.5%, respectively. Although discussions in the U.S. of how to mitigate the continued impact of COVID-19 have often pegged the economy against deaths among the elderly, the pandemic has also led to high excess mortality rates among younger people, including working age adults.
www.healthsystemtracker.org

COVID-19 pandemic-related excess mortality and potential years of life lost in the U.S. and peer countries - Peterson-KFF Health System Tracker

Researchers have used a variety of measures to assess the impact of the COVID-19 pandemic, including deaths directly attributed to COVID-19 infection and deaths in excess of prior years’ death rates. However, these measures do not incorporate the prematurity of deaths or differences in age at...
www.healthsystemtracker.org www.healthsystemtracker.org
 

Blood Type Risk - Not Found to Have an Association
Type 0 blood types have a reduced risk of developing COVID-19 - Now debunked - see below.
ashpublications.org

Reduced prevalence of SARS-CoV-2 infection in ABO blood group O

Key Points. Blood group O is associated with a decreased risk for contracting SARS-CoV-2 infection.
ashpublications.org ashpublications.org

Blood type was linked with severity of illness
ashpublications.org

association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19

Key Points. COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation vs those with blood group O or B.COVID-19 pati
ashpublications.org ashpublications.org

Meta-analysis of 10 eligible studies consisting of 54,218 subjects suggested that blood groups A and B are associated with an estimated increase in the probability of COVID-19 infection compared with non-A and non-B blood groups, which was statistically significant. However, compared with the non-O blood groups, individuals with blood group O had a significantly lower predisposition to COVID-19, which was highly statistically significant. No statistical evidence was found for an association between blood group AB and COVID-19 infection. In terms of Rh, patients who were Rh positive were more vulnerable to COVID-19 than those who were Rh negative. Furthermore, we found a contribution of ABO blood groups to the clinical outcome of patients with COVID-19. Compared with non-A blood groups, higher mortality was observed in patients with blood group A, suggesting that blood group A may be related to unfavourable outcomes.
www.sciencedirect.com

The impact of ABO blood group on COVID-19 infection risk and mortality: A systematic review and meta-analysis

The 2019 coronavirus disease (COVID-19) has become a global pandemic. Several studies report that ABO blood group polymorphism may be related to COVID…
www.sciencedirect.com www.sciencedirect.com

Latest - Not Found to Be Associated
A total of 107,796 persons across 24 hospitals and 215 clinics were included in the study. Overall, 11,468 of these patients tested positive for COVID-19.1 Researchers noted that while other demographic determinants played a role in hospitalization, intensive care unit (ICU) admission, and viral positivity, blood type was not associated with susceptibility to or severity of COVID-19.
 

Blood Type Risk - Not Found to Have an Association
Type 0 blood types have a reduced risk of developing COVID-19 - Now debunked - see below.
ashpublications.org

Reduced prevalence of SARS-CoV-2 infection in ABO blood group O

Key Points. Blood group O is associated with a decreased risk for contracting SARS-CoV-2 infection.
ashpublications.org ashpublications.org

Blood type was linked with severity of illness
ashpublications.org

association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19

Key Points. COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation vs those with blood group O or B.COVID-19 pati
ashpublications.org ashpublications.org

Meta-analysis of 10 eligible studies consisting of 54,218 subjects suggested that blood groups A and B are associated with an estimated increase in the probability of COVID-19 infection compared with non-A and non-B blood groups, which was statistically significant. However, compared with the non-O blood groups, individuals with blood group O had a significantly lower predisposition to COVID-19, which was highly statistically significant. No statistical evidence was found for an association between blood group AB and COVID-19 infection. In terms of Rh, patients who were Rh positive were more vulnerable to COVID-19 than those who were Rh negative. Furthermore, we found a contribution of ABO blood groups to the clinical outcome of patients with COVID-19. Compared with non-A blood groups, higher mortality was observed in patients with blood group A, suggesting that blood group A may be related to unfavourable outcomes.
www.sciencedirect.com

The impact of ABO blood group on COVID-19 infection risk and mortality: A systematic review and meta-analysis

The 2019 coronavirus disease (COVID-19) has become a global pandemic. Several studies report that ABO blood group polymorphism may be related to COVID…
www.sciencedirect.com www.sciencedirect.com

Latest - Not Found to Be Associated
A total of 107,796 persons across 24 hospitals and 215 clinics were included in the study. Overall, 11,468 of these patients tested positive for COVID-19.1 Researchers noted that while other demographic determinants played a role in hospitalization, intensive care unit (ICU) admission, and viral positivity, blood type was not associated with susceptibility to or severity of COVID-19.

 

Number of articles written about COVID-19 - Crazy!!

figure-1.jpg


consultqd.clevelandclinic.org

COVID-19 and the Rheumatologist: What Have We Learned?

Vaccination and post-acute sequelae of COVID-19 in patients with immune-mediated inflammatory diseases
consultqd.clevelandclinic.org consultqd.clevelandclinic.org
 

When do Vaccines Kick in?
Here’s some helpful data on how soon and completely protection occurs after vaccination with the mRNA vaccines. Clear benefit 2 weeks after 1st dose. By 3 weeks after 1st dose, most of the benefit already reached. Full protection occurs 1 week after 2nd shot.
View attachment 850113


Early T cell and binding antibody responses are associated with Covid-19 RNA vaccine efficacy onset​

Protective immunity must develop coincidentally with vaccine efficacy onset
80% of vaccinees develop Spike-binding antibodies at day 10 after the first dose
100% of vaccinees develop Spike-specific T cells at the same time point
Lack of neutralizing antibodies suggest they are not necessary to prevent Covid-19

 

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