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šŸ¦˜Cacatman's Personal Coronavirus COVID-19 Update Thread

Risk Factors - PCOS
Women with polycystic ovary syndrome (PCOS) face an almost 30% increased risk for COVID-19 compared with unaffected women, even after adjusting for cardiometabolic and other related factors, suggests an analysis of United Kingdom primary care data.
 
Post Vaccination Slackness!!!
Experts have called for stronger health warnings for people being vaccinated against covid-19 after observing a rise in infections shortly after vaccination, suggesting that many people are letting their guard down before the vaccine has taken effect.
 
Statins Increase Survival
Findings show 53 percent increased survival among patients using statins before hospitalization.

The researchers found that 36.2 percent of participants were antecedent statin users. In a propensity score-matched cohort of 1,296 patients (648 statin users and 648 nonusers), statin use was associated with significantly lower odds of the primary end point of in-hospital mortality within 30 days (odds ratio, 0.47), with the primary end point occurring in 14.8 and 26.5 percent of patients receiving statins and those not receiving statins, respectively. The secondary endpoint of invasive mechanical ventilation at 30 days occurred in 18.6 and 21.9 percent of patients receiving statins and those not receiving statins, respectively (odds ratio, 0.76).

Statins may be helpful for diabetic patients with COVID-19

In hospitalized COVID-19 patients with diabetes, statin use was associated with reduced inā€hospital mortality. If confirmed, these study findings may highlight the importance of administering statins to patients with diabetes and COVID-19.

This observational study included 4252 adult patients admitted to a single center in Bronx, New York from March 1, 2020 to May 2, 2020. Among non-diabetic patients, statin use did not significantly impact in-hospital mortality. Among diabetic patients on a statin, reduced cumulative in-hospital mortality was observed (24% vs 39%, P < .01). After propensity score matching and inverse probability treatment weighting, the risk of death during hospitalization was 12% lower for statin users than non-users.

ā€œWe conclude that antecedent statin use in patients hospitalized with COVID-19 is associated with lower inpatient mortality,ā€ the authors wrote. ā€œStatin use was significantly associated with a reduction in the primary endpoint (in-hospital mortality within 30 days) in the overall cohort in univariate (OR 0.69, 95% CI 0.56-0.85) and multivariable-adjusted analysis (OR 0.49, 95% CI 0.38ā€“0.63).ā€
 
Pre existing Tinnitus Can be Made Worse By COVID-19
Having COVID-19 symptoms exacerbated tinnitus in 40% of respondents, made no change in 54%, and improved tinnitus in 6%.

Tinnitus Connection with COVID-19
- caused by hearing loss, middle ear disorder, head & neck trauma, TMH, ototoxic medication, sinus pressure, traumatic brain injuries
- Brain "making up" for missing info
- Could be crickets, fleeting sound, caustic roaring sound, whooshing or static sounds
- Treatment - supplements are not effective
 
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Mix 'n Matching Vaccines
The 13 month study will initially have eight different arms, testing eight different combinations, but more products may be added:

  • Oxford/AstraZeneca and Oxford/AstraZeneca - 28 days apart
  • Oxford/AstraZeneca and Oxford/AstraZeneca - 12 weeks apart - as a control group
  • Pfizer/BioNTech and Pfizer/BioNTech - 28 days apart
  • Pfizer/BioNTech and Pfizer/BioNTech - 12 weeks apart - as a control group
  • Oxford/AstraZeneca and Pfizer/BioNTech - 28 days apart
  • Oxford/AstraZeneca and Pfizer/BioNTech - 12 weeks apart
  • Pfizer/BioNTech and Oxford/AstraZeneca - 28 days apart
  • Pfizer/BioNTech and Oxford/AstraZeneca - 12 weeks apart
 
Delay Surgery for 7 weeks Post COVID-19
  • A new study suggests that those who have been diagnosed with COVID-19 should wait at least 7 weeks before undergoing surgery to avoid a higher risk of postoperative death.
  • Death rates during the 30 days after surgery were 1.5 percent among those who had not developed COVID-19, and 4 percent among patients who had surgery within 4 weeks of diagnosis.
  • That rate dropped to 3.6 percent for those having surgery 5 to 6 weeks after surgery, and 1.5 percent among those having surgery 7 to 8 weeks after developing COVID-19.
 
Diabetes
Poor outcomes, increased mortality and severe COVID-19. More likely to die during hosptalisation
 
Asymptomatic/Presymptomatic Transmission

Half the Transmission of COVID-19 Comes from Asymptomatic People

Models predicts that 59% of all transmission would come from asymptomatic transmission ā€“ 35% from presymptomatic individuals and 24% from never-symptomatic individuals.

The authors acknowledge that the study applies a simplistic model to a complex and evolving phenomenon, and that the exact proportions of presymptomatic and never-symptomatic transmission and the incubation periods are not known. They also note symptoms and transmissions appear to vary across different population groups, with older individuals more likely than younger persons to experience symptoms, according to previous studies.

Asymptomatic cases more like 17-30%

Viral shedding kinetics for asymptomatic COVID-19 is not well understood. Early in infection, individuals have similar viral loads regardless of eventual symptom severity, but asymptomatic cases have lower titers at peak replication, faster viral clearance, and thus a shorter infectious period.

They are 42% less likely to transmit the virus and there are lower secondary attack rates. But this is controversial.

65% of transmission occurs prior to symptom onset!!
 
Report on Origins of COVID-19
Nevertheless, the WHO report discounts both Redfieldā€™s opinion and Blinkenā€™s misgivings. The report is largely based on a WHO investigator visit to Wuhan from mid-January to mid-February this year. The investigators detailed 4 scenarios by which SARS-CoV-2 could have emerged, listed in order of most likelihood to least:

  • Bats through another animal (very likely)
  • Direct spread from bats to humans (likely)
  • Cold-chain food products (possible but not likely)
  • Laboratory leak (extremely unlikely)
As the report draft explains, the evolutionary distance between bat-based coronaviruses and SARS-CoV-2 is estimated to be several decades, ā€œsuggesting a missing link.ā€

Intermediate hasn't been found.
 

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