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šŸ¦˜Cacatman's Personal Coronavirus COVID-19 Update Thread

Moderna Vaccine - Protective Against the Newer Strains
The two-dose regimen of the Moderna COVID-19 Vaccine at the 100 Āµg dose is expected to be protective against emerging strains detected to date.

Moderna announced today its mRNA-1273 COVID-19 vaccine does produce neutralizing titers against the B.1.1.7 (UK variant) and B.1.351 (South Africa variant). However, the company said there is a six-fold reduction in neutralizing titers in the latter variant.

Out of 100 people who get a Moderna shot, less than 1% develop a skin reaction of this type. After 8-10 days post vaccination. Treatment is supportive therapy only.

Antibodies are still present 6 months after 2nd dose

Good for 6 months

The vaccine proved 96% effective against Covid-19 hospitalization and 87% effective in preventing infection in a study of more than 700,000 individualsā€”half fully vaccinated, half unvaccinatedā€”at Kaiser Permanente Southern California, the company said, noting the delta variant made up 47% of the cases among vaccinated individuals.

The company also highlighted a recent study by the CDC of more than 33,000 medical encounters in nine states which found the Moderna vaccine to be more effective than others, with 95% efficacy against hospitalization and 92% efficacy against urgent care and emergency visits from Covid-19 (the delta variant was the dominant variant during this time).

Looking at more than 26,000 people who received at least one dose of the vaccine, Moderna found 162 breakthrough cases among the 16,747 vaccinated between July and August 2020 compared to 88 among the 11,431 inoculated between December 2020 and March 2021, meaning the rate of breakthrough infections was about 36% lower among those vaccinated more recently (when adjusted for the studyā€™s timing).
 
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Lung Transplants Can Save Some COVID-19 Survivors
Surgeons worldwide have been performing lung transplants in COVID-19 survivors with irreversible lung damage, and an international group of transplant experts has proposed guidelines for selection of eligible patients. To possibly qualify for a transplant, COVID-19 survivors with complete lung failure should be younger than 65, nonsmokers, and have no pre-existing medical conditions, or only manageable ones, they advise. They said transplants should be performed at least four weeks after a diagnosis of irreversible lung damage.
 

Home oxygen for patients with COVID-19 pneumonia conferred low mortality, readmission

Patients with COVID-19 pneumonia who were discharged from the hospital on home oxygen had low rates of mortality and readmission within 30 days, according to new data published in JAMA Network Open.
 

Denmark drops AstraZeneca as the first country

Denmark is the first country to drop the vaccine from AstraZeneca completely :oops:

:cool:šŸ‘ no chances taken
 
B1.1.7 British Variant
SARS-CoV-2, B.1.1.7, or otherwise known as VOC 202012/01, which was discovered in the United Kingdom back in December may lead to a large increase in the number of COVID-19 cases.
Investigators have said B.1.1.7 is more contagious than the original virus, but no determination has been made that this variant can lead to severe cases and higher mortality.

It is between 30% and 100% more deadly than previous dominant variants. It has 23 mutations in its genetic code - a relatively high number - and some of them have made it far more easily spread. Scientists say it is about 40%-70% more transmissible than previous dominant variants that were circulating.

64% higher risk of dying from it.

17 mutations, 4 mutations affect viral function and enhances virus binding affinity to ACE 2.

It is about 55-74% more infective

COVID latches on to cells with spike proteins. The B.1.1.7 (UK variant) needs less amount of virus to make you sick ie they're stickier. Implications are that you may have a briefer or smaller exposure and get infected and because it's "stickier", you may get a higher viral load which will increase the chance of death as well as making you more infective. This is why more young people will potentially die if we aren't careful.
 

Low HDL and high triglycerides predict COVID-19 severity


 
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